407 research outputs found
GHRS and ORFEUS-II Observations of the Highly Ionized Interstellar Medium Toward ESO141-055
We present Goddard High Resolution Spectrograph and ORFEUS-II measurements of
Si IV, CIV, N V, and O VI absorption in the interstellar medium of the Galactic
disk and halo toward the nucleus of the Seyfert galaxy ESO141-055. The high
ionization absorption is strong, with line strengths consistent with the
spectral signature expected for hot (log T = 5-6) collisionally ionized gas in
either a ``Galactic fountain'' or an inhomogeneous medium containing a mixture
of conductive interfaces and turbulent mixing layers. The total O VI column
density of log N ~ 15 suggests that the scale height of O VI is large (>3 kpc)
in this direction. Comparison of the high ion column densities with
measurements for other sight lines indicates that the highly ionized gas
distribution is patchy. The amount of O VI perpendicular to the Galactic plane
varies by at least a factor of ~4 among the complete halo sight lines thus far
studied. In addition to the high ion absorption, lines of low ionization
species are also present in the spectra. With the possible exception of Ar I,
which may have a lower than expected abundance resulting from partial
photoionization of gas along the sight line, the absorption strengths are
typical of those expected for the warm, neutral interstellar medium. The sight
line intercepts a cold molecular cloud with log N(H2) ~ 19. The cloud has an
identifiable counterpart in IRAS 100-micron emission maps of this region of the
sky. We detect a Ly-alpha absorber associated with ESO141-055 at z = 0.03492.
This study presents an enticing glimpse into the interstellar and intergalactic
absorption patterns that will be observed at high spectral resolution by the
Far Ultraviolet Spectroscopic Explorer.Comment: 24 pages + 8 figures, uses aaspp4.sty. Accepted for publication in
Ap
Galectin-3 interacts with the cell surface glycoprotein CD146 (MCAM, MUC18) and induces secretion of metastasis-promoting cytokines from vascular endothelial cells
The galactoside-binding protein galectin-3 is increasingly recognized as an important player in cancer development, progression, and metastasis via its interactions with various galactoside-terminated glycans. We have shown previously that circulating galectin-3, which is increased up to 30-fold in cancer patients, promotes blood-borne metastasis in an animal cancer model. This effect is partly attributable to the interaction of galectin-3 with unknown receptor(s) on vascular endothelial cells and causes endothelial secretion of several metastasis-promoting cytokines. Here we sought to identify the galectin-3-binding molecule(s) on the endothelial cell surface responsible for the galectin-3-mediated cytokine secretion. Using two different galectin-3 affinity purification processes, we extracted four cell membrane glycoproteins, CD146/melanoma cell adhesion molecule (MCAM)/MUC18, CD31/platelet endothelial cell adhesion molecule-1 (PECAM-1), CD144/VE-cadherin, and CD106/Endoglin, from vascular endothelial cells. CD146 was the major galectin-3-binding ligand and strongly co-localized with galectin-3 on endothelial cell surfaces treated with exogenous galectin-3. Moreover, galectin-3 bound to N-linked glycans on CD146 and induced CD146 dimerization and subsequent activation of AKT signaling. siRNA-mediated suppression of CD146 expression completely abolished the galectin-3-induced secretion of IL-6 and G-CSF cytokines from the endothelial cells. Thus, CD146/MCAM is the functional galectin-3-binding ligand on endothelial cell surfaces responsible for galectin-3-induced secretion of metastasis-promoting cytokines. We conclude that CD146/MCAM interactions with circulating galectin-3 may have an important influence on cancer progression and metastasis
The Object Management Group Ontology Definition Metamodel
Report of a submission being made to a major international software engineering standards group, the Object Management Group which ties together OMG standards with World-Wide Web Consortium and International Standards Organization standards. Major industry bodies including IBM are collaborating, and the submission has the support of 24 companies. OMG, W3C and ISO standards strongly influence the industry, especially in combination. Colomb was a major contributor, responsible for 30% of the submission, and the primary author of the paper
The Leiden/Argentine/Bonn (LAB) Survey of Galactic HI: Final data release of the combined LDS and IAR surveys with improved stray-radiation corrections
We present the final data release of observations of lambda 21-cm emission
from Galactic neutral hydrogen over the entire sky, merging the
Leiden/Dwingeloo Survey (LDS: Hartmann & Burton, 1997) of the sky north of
delta = -30 deg with the Instituto Argentino de Radioastronomia Survey (IAR:
Arnal et al., 2000, and Bajaja et al., 2005) of the sky south of delta = -25
deg. The angular resolution of the combined material is HPBW ~ 0.6 deg. The LSR
velocity coverage spans the interval -450 km/s to +400 km/s, at a resolution of
1.3 km/s. The data were corrected for stray radiation at the Institute for
Radioastronomy of the University of Bonn, refining the original correction
applied to the LDS. The rms brightness-temperature noise of the merged database
is 0.07 - 0.09 K. Residual errors in the profile wings due to defects in the
correction for stray radiation are for most of the data below a level of 20 -
40 mK. It would be necessary to construct a telescope with a main beam
efficiency of eta_{MB} > 99% to achieve the same accuracy. The merged and
refined material entering the LAB Survey of Galactic HI is intended to be a
general resource useful to a wide range of studies of the physical and
structural characteristices of the Galactic interstellar environment. The LAB
Survey is the most sensitive Milky Way HI survey to date, with the most
extensive coverage both spatially and kinematically.Comment: 9 pages, 5 figures, accepted for publication by Astronomy &
Astrophysic
Intercultural New Media Studies: The Next Frontier in intercultural Communication
New media (ICT\u27s) are transforming communication across cultures. Despite this revolution in cross cultural contact, communication researchers have largely ignored the impact of new media on intercultural communication. This groundbreaking article defines the parameters of a new field of inquiry called Intercultural New Media Studies (INMS), which explores the intersection between ICT\u27s and intercultural communication. Composed of two research areasâ(1) new media and intercultural communication theory and (2) culture and new mediaâINMS investigates new digital theories of intercultural contact as well as refines and expands twentieth-century intercultural communication theories, examining their salience in a digital world. INMS promises to increase our understanding of intercultural communication in a new media age and is the next frontier in intercultural communication
Seasonal variations in aerosol particle composition at the puy-de-DĂŽme research station in France
Detailed investigations of the chemical and microphysical properties of atmospheric aerosol particles were performed at the puy-de-DĂŽme (pdD) research station (1465 m) in autumn (September and October 2008), winter (February and March 2009), and summer (June 2010) using a compact Time-of-Flight Aerosol Mass Spectrometer (cToF-AMS). Over the three campaigns, the average mass concentrations of the non-refractory submicron particles ranged from 10 ÎŒg m<sup>&minus;3</sup> up to 27 ÎŒg m<sup>&minus;3</sup>. Highest nitrate and ammonium mass concentrations were measured during the winter and during periods when marine modified airmasses were arriving at the site, whereas highest concentrations of organic particles were measured during the summer and during periods when continental airmasses arrived at the site. The measurements reported in this paper show that atmospheric particle composition is strongly influenced by both the season and the origin of the airmass. The total organic mass spectra were analysed using positive matrix factorisation to separate individual organic components contributing to the overall organic particle mass concentrations. These organic components include a low volatility oxygenated organic aerosol particle (LV-OOA) and a semi-volatile organic aerosol particle (SV-OOA). Correlations of the LV-OOA components with fragments of <i>m/z</i> 60 and <i>m/z</i> 73 (mass spectral markers of wood burning) during the winter campaign suggest that wintertime LV-OOA are related to aged biomass burning emissions, whereas organic aerosol particles measured during the summer are likely linked to biogenic sources. Equivalent potential temperature calculations, gas-phase, and LIDAR measurements define whether the research site is in the planetary boundary layer (PBL) or in the free troposphere (FT)/residual layer (RL). We observe that SV-OOA and nitrate particles are associated with air masses arriving from the PBL where as particle composition measured from RL/FT airmasses contain high mass fractions of sulphate and LV-OOA. This study provides unique insights into the effects of season and airmass variability on regional aerosol particles measured at an elevated site
Trainâtheâtrainer: Methodology to learn the cognitive interview
Research has indicated that police may not receive enough training in interviewing cooperative witnesses, specifically in use of the cognitive interview (CI). Practically, for the CI to be effective in realâworld investigations, police investigators must be trained by law enforcement trainers. We conducted a threeâphase experiment to examine the feasibility of training experienced law enforcement trainers who would then train others to conduct the CI. We instructed Federal Bureau of Investigation and local law enforcement trainers about the CI (Phase I); law enforcement trainers from both agencies (n = 4, 100% male, mean age = 50 years) instructed university students (n = 25, 59% female, mean age = 21 years) to conduct either the CI or a standard law enforcement interview (Phase II); the student interviewers then interviewed other student witnesses (n = 50, 73% female, mean age = 22 years), who had watched a simulated crime (phase III). Compared with standard training, interviews conducted by those trained by CIâtrained instructors contained more information and at a higher accuracy rate and with fewer suggestive questions.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/147804/1/jip1518_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/147804/2/jip1518.pd
When will 'open science' become simply 'science'?
Open science describes the practice of carrying out scientific research in a completely transparent manner, and making the results of that research available to everyone. Isnât that just âscienceâ
- âŠ